San Francisco 49ers WR Christian Kirk (calf) and OT Austen Pleasants (undisclosed) were placed on the Reserve/Injured list Sunday, Aug. 30, but have been designated to return. The Team also placed C Brett Toth (concussion) and OT Nick Zakelj (elbow) on the Reserve/Injured list and RB Isaac Guerendo (pectoral) and DE Mykel Williams (knee) on Reserve/Physically Unable to Perform list.

San Francisco 49ers DE Mykel Williams (knee) is a candidate to start the regular season on the Reserve/Physically Unable to Perform list, in the opinion of ESPN.com's Nick Wagoner.

San Francisco 49ers DE Mykel Williams (knee) is a "longshot" to play in Week 1, according to head coach Kyle Shanahan.

San Francisco 49ers DE Mykel Williams (knee) is aiming for a Week 1 return from the Physically Unable to Perform list, according to general manager John Lynch.

San Francisco 49ers DE Mykel Williams (knee) and DT Alfred Collins (shoulder) were placed on the Active/Physically Unable to Perform list Saturday, July 25.

Las Vegas Raiders DE Maxx Crosby could be of interest to the San Francisco 49ers, if the Raiders decide to move him this offseason, according to Vincent Bonsignore of the New York Post. Multiple league sources believe that the framework for a deal could include a 2027 first-round draft pick, a 2028 second-round draft pick and DE Mykel Williams for Crosby.

San Francisco 49ers LB Mykel Williams (knee) is still recovering from a torn anterior cruciate ligament and will be a candidate to start for the Reserve/Physically Unable to Perform list if he is not cleared to play, in the opinion of NBC Sports Bay Area's Matt Maiocco.

Auburn University DE Keldric Faulk has been compared to Buffalo Bills DE Gregory Rousseau and San Francisco 49ers DE Mykel Williams by scouts who spoke with Jordan Reid of ESPN.com, and Reid believes Faulk could be a target for the Kansas City Chiefs and Cincinnati Bengals in the first round of the 2026 NFL Draft.

San Francisco 49ers LB Mykel Williams (knee) said he believes he will be ready to return to the field around training camp.

San Francisco 49ers OG Ben Bartch (ankle) was activated from the Reserve/Injured list Saturday, Nov. 8. The team also placed DE Mykel Williams (knee) on the Reserve/Injured list.