Huddle Up: Friday's practice was a walk-through, so the team essentially carried over every player's practice designation from Thursday's session. With that said, it is not looking good for the third-year back, especially considering how much running backs need their toes to be healthy in order to play at a high level. Ray Davis would likely lead the backfield in touches if Cook cannot go, but that is not a given since Ty Johnson has been running ahead of him for most of the season. Both players would likely be no better than flex options if Cook sits this week.

Huddle Up: Friday's practice was a walk-through, so the team essentially carried over every player's practice designation from Thursday's session. It means we will have to wait until Saturday's final injury report before we know if Shakir has a shot to play on Monday night against the New York Jets. Since it is a Monday night game, however, fantasy managers should plan on being without him for at least one more game.

Huddle Up: Shakir was not able to play in the last game and may sit again if he does not practice this week. Fantasy players should monitor the situation because he can be a starting option in fantasy leagues when healthy.

Huddle Up: Cook also missed practice on Wednesday, which is an ominous sign that he may not be able to get right in time to play on Monday night against the New York Jets. In addition to being the latest game of the week, the problem for fantasy managers is that Cook's direct backup is a bit of an unknown. Ray Davis would seem to be the most likely player to handle most of the work, but Ty Johnson has generally played ahead of him through the first five games. For now, Cook's managers should prepare to be without him this week.

Huddle Up: Fantasy players will need to monitor Shakir's practice participation during the week to see if he will be available for the Week 6 game. He has been one of the main options in the Bills passing game when healthy and should be a starting option if active.

Huddle Up: Kincaid has been targeted at least five times in each of the last three games but has been held to under 50 yards in each of those games. He should continue to see a decent amount of targets each game and can be a low-end No. 1 tight end in some leagues.

Huddle Up: Coleman has not been a big factor in the passing game this season but does have two touchdowns in the last three games. He probably will see a few more targets as the season moves on but is not a strong fantasy option.

Huddle Up: Cook posted season highs in rushing attempts and yards this week and has a touchdown in three of the last four games. He will continue to be a big part of the offense and should be at least a flex option in all fantasy leagues.

Huddle Up: Fantasy players should keep an eye on the situation because Allen appeared to be banged up during the game but only missed one play. He had a disappointing Week 5 performance but is still one of the top quarterbacks in the NFL and should be a weekly starting option.

Huddle Up: Allen has played well so far this season and should continue to post good numbers even though he will be without one of his receivers. He should be a starting option in all fantasy leagues.

Huddle Up: With Shakir out, managers will have to pivot for a potential flex option. Curtis Samuel should see some increased usage, but he's likely a risky WR4/5 type. This should make for a nice bump in targets for Dalton Kincaid and Keon Coleman.

Huddle Up: Allen has been one of the most productive quarterbacks in the NFL during the first quarter of the season and is a must-start option in all fantasy leagues as long as he is healthy.

Huddle Up: It is looking like Shakir will be questionable at best for the Week 5 game, so fantasy players may want to look for other options to use in their lineups this week.

Huddle Up: Allen was not able to find the end zone this past week but has still been one of the top quarterbacks in the NFL during the first quarter of the season. He is a must-start option in all leagues as long as he is healthy.

Huddle Up: Shakir has been a reliable option for the Bills so far this season, so fantasy players should keep an eye on his status. He could be a possible flex option in some deeper leagues if he plays.

Huddle Up: At this point, Samuel belongs on waivers. Somehow, the same offensive coordinator who oversaw his career year in 2020 (77 catches, 851 yards and three touchdowns to go along with 200 yards rushing and two more TDs) cannot find a way to keep him involved in his age-28 season. With no more than three catches or 22 total yards in any game so far this year, Samuel belongs on the waiver wire in fantasy.

Huddle Up: The Bills made a concerted effort to get Kincaid involved early, targeting him four times on the first two possessions, but Buffalo had trouble putting together a drive over 40 yards in this one. Given the low floor of the tight end position in fantasy so far, Kincaid has been a bit of a bright spot in the last two weeks with a combined eight catches for 88 yards and a touchdown. He should remain firmly in the TE1 discussion in Week 5 against the Houston Texans.

Huddle Up: Shakir did most of his damage on a scramble drill play in which he got behind the defense for a 51-yard catch-and-run that left him three yards shy of scoring a touchdown. Considering how bad of a day it was for the Buffalo offense, fantasy managers should be happy to get what they did from the third-year pro. A Week 5 matchup against the Houston Texans is not any easier for the Bills, but Shakir is a big enough part of the offense to be a serviceable fantasy WR3 again.

Huddle Up: Coleman showed some chemistry with Josh Allen on a pair of back-shoulder fades, but Buffalo's offense had trouble sustaining much of anything in this one. With that said, there is hope for the rookie in fantasy after all - even if he falls behind Khalil Shakir and Dalton Kincaid in the passing game pecking order. There might be a time in the future when Coleman is worth starting every week, but it should not be in Week 5 versus the Houston Texans.

Huddle Up: Six of Davis' carries came in the final two minutes of the game, so it is safe to say he wasn't seeing much time over the first three quarters. For whatever reason, Buffalo has yet to give him much work despite drafting him to take some punishment off the plates of Josh Allen and James Cook. Fantasy managers in deeper leagues can continue to hold, but it looks like it will take an injury to Cook before Davis has a shot of being relevant.

Huddle Up: The game got away quickly from the Bills, although that does not explain why Cook wasn't more involved in the passing game. Perhaps Buffalo's biggest issue was only running 57 plays, which included several runs during the fourth quarter with the game no longer in doubt. Cook's only chance of possibly saving his fantasy day ended up being a 3-yard touchdown run for Ty Johnson instead. The third-year back was probably due for some negative touchdown regression after matching last season's touchdown total over the last two games. Expect Cook to bounce back with more respectable RB2 numbers in Week 5 versus the Houston Texans.

Huddle Up: Even though he only took three sacks, Allen was on the run quite a bit in this one, which is all Baltimore had to stop after mostly shutting down the Bills' rushing attack. Allen has been extremely up-and-down for fantasy purposes through four games, although this is the first time in nearly three seasons that he did not account for a touchdown running or throwing. Fantasy managers have little choice but to shake this one off and believe the offense will operate at a much higher level in Week 5 against the Houston Texans.

Huddle Up: Allen has practiced in full for three straight weeks since suffering the injury in Week 1, so it is fair to say it is a non-issue at this point. He is a great candidate to be the overall QB1 every week he suits up, although that kind of performance does not usually happen against the Ravens. Either way, he is a must-start every week he can take the field.

Huddle Up: Allen has been one of the best quarterbacks in the NFL over the first three games and is a must-start option in all fantasy leagues no matter the opponent.

Huddle Up: Allen has been one of the best players in the NFL during the early part of the season with nine total touchdowns in three games. He is a must-start option in all fantasy leagues.

Huddle Up: The touchdown was nice, but he needs more targets to have any fantasy appeal outside of the deepest leagues and dynasty formats. Khalil Shakir has emerged as the WR1 in Buffalo, but there is plenty of room for Coleman to grow and carve a role out for himself.

Huddle Up: Kincaid has seen his receiving yardage steadily rise in each game this season, and the touchdown was his first. He is still more of a TE2 heading into Week 4 against the Baltimore Ravens, but he does have some upside, and could re-emerge as a TE1 if he continues his ascent.

Huddle Up: Shakir has seen his receptions and yardage totals go up in each of the three games so far, and he has scored in two of those outings. He is a solid WR3 or flex fantasy option heading into Week 4 against the Baltimore Ravens.