Huddle Up: With Jordan James battling injuries throughout the preseason, Black appears to have claimed the No. 2 running back role. Black started the preseason finale ahead of James, and given Christian McCaffrey's injury history, Black should be stashed in all formats.

Huddle Up: Evans has battled some minor injuries during training camp, but it sounds like he should be ready for the opener. Assuming he can stay healthy, he will have WR2 upside as one of the main options in the San Francisco passing attack.

Huddle Up: 49ers coach Kyle Shanahan indicated Evans should be back to practice next week before leaving for Australia. Consider him a mid-range WR2 for fantasy with the hope that he still has a lot of gas left in the tank in his 13th NFL season and first with the 49ers.

Huddle Up: It's great news to see McCaffrey on the practice field, especially if you have an early pick on draft day in fantasy leagues. If you're picking 1.01 or 1.02, going with Bijan Robinson of the Atlanta Falcons, Jahmyr Gibbs of the Detroit Lions or even Ja'Marr Chase of the Cincinnati Bengals might be a safer option. However, McCaffrey still gets the job done in PPR formats, and there is no reason to believe he won't see a lion's share of the backfield touches in San Francisco again in 2026, with only rookie Kaelon Black and veterans Isaac Guerendo and Jordan James as backups.

Huddle Up: Stribling's fantasy stock has been on the rise all throughout training camp and the preseason, with some talking heads opining that he could end up as the No. 1 receiver option, even ahead of Mike Evans. Let's pump the brakes until we start seeing production in meaningful games, but the upside is certainly there. He is worth scooping up on draft day in the middle rounds in all leagues for his potential, and he is obviously a must-have in long-term keeper formats.

Huddle Up: While Kittle may or may not play in the opener, the good news is that Kittle will not have to miss the first month of the regular season. If you plan to draft Kittle in your fantasy draft, or you have already done so, plan to have some early-season depth at the position. It might not even be a bad idea to have Jake Tonges on hand as a reserve, just in case.

Huddle Up: A great piece of news for the 49ers as they've been banged up throughout their receiving corps all training camp and preseason. Evans returning to practice is huge for them and you can consider him a mid-range WR2 for fantasy with the hope that he still has a lot of gas left in the tank in his 13th NFL season and first with the 49ers.

Huddle Up: The hype train for Stribling has been running full steam ahead for weeks, so hopefully this injury isn't something that can derail him. Stribling has a real opportunity to see meaningful time on offense with plenty of injuries across the 49ers' offensive skill position players. Think of Stribling as a middle-round sleeper with a wide range of outcomes this season, but one worth taking a shot on in a good San Francisco 49ers offense for fantasy football.

Huddle Up: Black, who recently returned from a groin injury, is part of the competition to back up Christian McCaffrey alongside names like Jordan James (ribs), Isaac Guerendo (pec), and Zamir White. Whoever earns that job will be a priority handcuff selection for CMC owners given the veteran's durability concerns. If you're drafting before the team names a backup, Black, a third-round pick, seems like the best bet at this stage.

Huddle Up: The hype has been building around Stribling throughout the offseason, and his solid showing Thursday will add fuel to the fire. It wouldn't be a surprise to see him carve out a role in the offense sooner rather than later, and Stribling seems well worth a flier in the later rounds.

Huddle Up: Purdy has dealt with injuries, but he has typically delivered solid results when he is on the field. Purdy can be a low-end QB1, but you may want to pair him with a reliable backup option.

Huddle Up: Evans has been a bastion of consistency in his NFL career, starting out his career with 11 consecutive 1,000-yard seasons before losing a huge chunk of time in 2025 with a hamstring strain, concussion and a broken collarbone. Joining the 49ers in 2026, Evans is in uncharted water heading into his age-33 season with a new team. For fantasy purposes, a healthy Evans is a low-end WR2 with flashes of WR1 upside this season.

Huddle Up: It appears McCaffrey is healthy despite missing time ahead of the new season. Fantasy players should still feel confident that he can be an RB1 this season.

Huddle Up: Kittle is still touch-and-go during training camp, and there remains hope he'll be ready for the regular season opener. While Kittle is worth drafting as a low-end TE1 due to his health status, we all know what he can do when he is 100 percent. If you draft him in the middle rounds on draft day, just make sure to have an alternate plan in the event he is unavailable for the regular-season opener.

Huddle Up: Evans has missed time during camp because of the injury but seems to have recovered from the injury. He will be the main receiver for the 49ers this season and can be a No. 2 or No. 3 receiver in fantasy leagues.

Huddle Up: McCaffrey does not appear to be dealing with any serious issues, but fantasy players should check on his status later in the week. He was one of the top players in fantasy football last season and will see plenty of touches again this season. He will be one of the first players selected in leagues and is a must-start weekly option.

Huddle Up: Evans projects as a WR for the 49ers when healthy, but the soft tissue injuries continue to pile up. Fantasy players should monitor his health this preseason and make sure to have a backup plan for the regular season in case more issues arise.

Huddle Up: McCaffrey does not appear to be dealing with any serious issues, but fantasy players should check on his status later in the week. He was one of the top players in fantasy football last season and will see plenty of touches again this season. He will be one of the first players selected in leagues and is a must-start weekly option.

Huddle Up: With Ricky Pearsall recovering from knee surgery to repair a posterior cruciate ligament, the door is open for the rookie Stribling to secure a meaningful role in the offense. Veterans Mike Evans and Christian Kirk are expected to start, and Deebo Samuel is back, and obviously knows the offense well. But, it could be argued that Stribling has the most upside of all of those players. Stribling should be considered as a WR5 with upside, worthy of fantasy consideration in redraft leagues. He has much more value in long-term dynasty formats, however.

Huddle Up: The team isn't interested in getting Evans on the field for preseason games, as they know what he is able to do. They're more interesting in getting Evans ready for the regular-season opener Sept. 10 against the Los Angeles Rams in the game Down Under in Melbourne, Australia. Evans will turn 33 years old on Aug. 21, but even at this advanced age for the NFL, he should again be productive for fantasy managers. Target him as a low-end WR2 or flex fantasy option, and hope he can continue to defy Father Time with his new organization. Make sure to have alternate options on hand, however, just in case.

Huddle Up: Kirk is vying for a big role in the San Francisco offense opposite fellow offseason acquisition Mike Evans, who is also sidelined with a quadriceps injury. Deebo Samuel is also in the mix, as well as Jacob Cowing, DeMarcus Robinson, rookie De'Zhaun Stribling and Jordan Wilkins. If Kirk has win a starting job, he could be a low-key fantasy sleeper worth nabbing in the middle to late rounds. He could surprise if he is able to stay healthy.

Huddle Up: Stribling has a chance, if he is healthy, to step up and become the 49ers' WR2 with Ricky Pearsall out for the year. If he steps into that role through camp, he could be an interesting WR3 or flex option in lineups.

Huddle Up: Stribling is dealing with a soft tissue injury, so the team is unlikely to rush his recovery with the regular season over a month away. Stribling in line for a bigger role with Ricky Pearsall out for the season and can be a late round pick in fantasy leagues.

Huddle Up: The 49ers will likely take their time with Evans because he is a veteran, so fantasy players should keep an eye on his status over the next few weeks. He will be the main receiver for the 49ers when he is ready to play and can be at least a No. 3 receiver in fantasy leagues.

Huddle Up: Samuel, who will turn 31 in January, has averaged 804 yards and 5 TDs over the last two seasons, and it would be overly optimistic to expect much beyond that in 2026. The fact that the 49ers are willing to use Samuel as their full-time returner provides some insight into how they view his role on offense -- suffice to say, if they were going to feature Samuel, they'd almost certainly look to limit his work on special teams. At best, you can consider using a late-round pick on Samuel, though a spot on your watch list might be a better choice.

Huddle Up: With Pearsall to miss all of 2026, he's a nonfactor in standard formats. For those in keeper leagues, however, the prudent move would be to keep Pearsall on an IR slot if you can spare the room. He's flashed when healthy, and he'll likely be playing for his NFL future (and a second contract, unless the 49ers unexpectedly exercise his fifth-year option) next year. Motivation doesn't get much higher.

Huddle Up: Aiyuk can essentially force the 49ers' hand at any time, though to this point he has elected not to, being content to air his greivences via social media. With no timetable for a resolution, Aiyuk remains nothing more than a final-round flier fantasy owners can stash on their bench.

Huddle Up: The team will likely be cautious with Stribling because of the type of injury, so fantasy players can check on his status later this week or next week. He is in line for a bigger role this season with Ricky Pearsall not available and could be a late round pick in deeper leagues.

Huddle Up: Evans will likely receive plenty of time to recover since it is early in training camp, but fantasy players can keep an eye on the situation. He will be the top receiver for the 49ers this season and can be at least a No.3 receiver in fantasy leagues if healthy.