San Francisco 49ers S Malik Mustapha (knee) and S Talanoa Hufanga (concussion) suffered injuries during the Week 18 game against the Arizona Cardinals.

San Francisco 49ers DE Robert Beal Jr. (ankle), OG Spencer Burford (calf), CB Deommodore Lenoir (shoulder), QB Brock Purdy (elbow) and WR Deebo Samuel (rib, wrist) did not take part in practice on Friday, Jan. 3, and were ruled out for Week 18. Also, LB Demetrius Flannigan-Fowles (calf) did not practice and is doubtful, TE George Kittle (ankle, hamstring), OT Colton McKivitz (knee), CB Isaac Yiadom (pelvis) and S Ji'Ayir Brown (ankle) were limited and are questionable and DE Nick Bosa (knee), DE Leonard Floyd (shoulder), WR Ricky Pearsall (illness, chest), RB Isaac Guerendo (foot, hamstring) and S Talanoa Hufanga (wrist) practiced in full and were removed from the injury report.

San Francisco 49ers DE Robert Beal Jr. (ankle), DE Nick Bosa (knee), OG Spencer Burford (calf), LB Demetrius Flannigan-Fowles (calf), DE Leonard Floyd (shoulder), CB Deommodore Lenoir (shoulder), OT Colton McKivitz (knee), QB Brock Purdy (elbow), WR Deebo Samuel (rib, wrist) and S Ji'Ayir Brown (ankle) did not participate in practice Thursday, Jan. 2. TE George Kittle (ankle, hamstring), CB Isaac Yiadom (pelvis) and WR Ricky Pearsall (chest, illness) were limited during practice. RB Isaac Guerendo (foot, hamstring) and S Talanoa Hufanga (wrist) fully participated in practice.

San Francisco 49ers DL Robert Beal Jr. (ankle), DE Nick Bosa (knee), OG Spencer Burford (calf), LB Demetrius Flannigan-Fowles (calf), LB Leonard Floyd (shoulder), CB Deommodore Lenoir (shoulder), OT Colton McKivitz (knee) and CB Isaac Yiadom (pelvis) did not practice Wednesday, Jan. 1. S Ji'Ayir Brown (ankle) was limited, and S Talanoa Hufanga (wrist) was a full participant.

San Francisco 49ers OL Aaron Banks (knee), DL Robert Beal Jr. (ankle), OL Spencer Burford (calf) and LB Dre Greenlaw (calf) did not take part in practice on Saturday, Dec. 28, and were ruled out for Week 17. Also, S Ji'Ayir Brown (ankle), CB Charvarius Ward (personal) and OL Colton McKivitz (knee) did not practice but are questionable, LB Tatum Bethune (knee) practiced in full but is questionable and DL Leonard Floyd (shoulder), RB Isaac Guerendo (foot, hamstring), DE Nick Bosa (hip, oblique), DL Jordan Elliott (knee), S Talanoa Hufanga (wrist), LB Dee Winters (chest) and FB Kyle Juszczyk (illness) practiced in full and were removed from the injury report.

San Francisco 49ers OG Aaron Banks (knee), DE Robert Beal Jr. (ankle), OG Spencer Burford (calf), LB Dre Greenlaw (calf), OT Colton McKivitz (knee) and FB Kyle Juszczyk (illness) did not participate in practice Friday, Dec. 27. S Ji'Ayir Brown (ankle), DE Leonard Floyd (shoulder) and RB Isaac Guerendo (foot, hamstring) were limited during practice. LB Tatum Bethune (knee), DE Nick Bosa (hip, oblique), DT Jordan Elliott (knee), S Talanoa Hufanga (wrist) and LB Dee Winters (chest) fully participated in practice.

San Francisco 49ers OG Aaron Banks (knee), DE Robert Beal Jr. (ankle), OG Spencer Burford (calf) and LB Dre Greenlaw (calf) did not participate in practice Thursday, Dec. 26. S Ji'Ayir Brown (ankle), LB Leonard Floyd (shoulder), RB Isaac Guerendo (foot, hamstring) and OT Colton McKivitz (knee) were limited during practice. LB Tatum Bethune (knee), DE Nick Bosa (hip, oblique), DT Jordan Elliott (knee), S Talanoa Hufanga (wrist) and LB Dee Winters (chest) fully participated in practice.

San Francisco 49ers RB Isaac Guerendo (foot, hamstring) and OT Trent Williams (ankle) did not practice on Friday, Dec. 20, and were ruled out for Week 16. Also, DL Robert Beal Jr. (ankle), DE Nick Bosa (hip, oblique) and LB Dre Greenlaw (Achilles, knee) were limited and are questionable and OG Aaron Banks (elbow), S Ji'Ayir Brown (groin), DT Maliek Collins (illness), LB Demetrius Flannigan-Fowles (knee), S Talanoa Hufanga (wrist), OT Jaylon Moore (hip), S Malik Mustapha (chest), LB Dee Winters (neck) and OG Nick Zakelj (illness) practiced in full and were removed from the injury report.

San Francisco 49ers DE Nick Bosa (hip, oblique), DT Maliek Collins (illness) and OT Trent Williams (ankle) did not participate in practice Thursday, Dec. 19. LB Dre Greenlaw (Achilles, knee), OT Jaylon X. Moore (hip), S Malik Mustapha (chest) and OG Nick Zakelj (illness) were limited during practice. OG Aaron Banks (elbow), S Ji'Ayir Brown (groin), LB Demetrius Flannigan-Fowles (knee), S Talanoa Hufanga (wrist) and LB Dee Winters (neck) fully participated in practice.

San Francisco 49ers DT Maliek Collins (illness) and OT Trent Williams (ankle) did not participate in practice Wednesday, Dec. 18. DE Nick Bosa (hip, oblique), LB Dre Greenlaw (Achilles, knee), OT Jaylon X. Moore (hip), S Malik Mustapha (chest) and OT Nick Zakelj (illness) were limited during practice. OG Aaron Banks (elbow), S Ji'Ayir Brown (groin), LB Demetrius Flannigan-Fowles (knee), S Talanoa Hufanga (wrist) and LB Dee Winters (neck) fully participated in practice.