Huddle Up: Guerendo will likely see a lion's share of the carries with CMC and Mason on the shelf, while it wouldn't be surprising to see Deebo Samuel reprise his role in the backfield. If you have FAAB remaining, it's a good idea to use a good percentage of what is left to secure Guerendo. He won't have much competition for carries, and he has RB1 fantasy ability, as the 49ers like to run the football.

Huddle Up: Guerendo appears to be set for action as the primary backup down the stretch behind Jordan Mason, as early reports indicate Christian McCaffrey might have suffered a season-ending knee injury in the first half. Guerendo is worth adding in deeper fantasy leagues, as he is just one Mason injury away from a big role.

Huddle Up: Guerendo came on in relief of Jordan Mason (shoulder), who did not return after logging six carries. The rookie continued to show his burst with three runs of at least 14 yards. Guerendo has likely done enough to justify the team's faith in him as Christian McCaffrey's long-term backup, but he will likely be fighting for scraps when the team returns from its Week 9 bye because CMC is set to return.

Huddle Up: With Robert Mason (shoulder) suffering a shoulder injury before halftime, Guerendo and Patrick Taylor handed the running back duties on Thursday night. While Guerendo's numbers are impressive, bear in mind that 76 yards came on one carry with Seattle crowding the line of scrimmage in a last-ditch effort to force the 49ers to punt. His other eight carries covered just 23 yards (2.9 YPC). The rookie's value for Week 7 and beyond depends on Mason's medical outlook. If he's cleared to play versus the Chiefs, Guerendo's appeal is nominal. If Mason is set to miss time, the Louisville product would be worth grabbing as Christian McCaffrey (Achilles) sounds like he's still weeks away from returning.