Isaac Guerendo
Running Back
Ht: 6' 0" Wt: 221 Age: 25 Exp: 0 years College: Louisville Drafted: 2024 R4 129
Avg FF PTS
N/A
Per Game
Cumulative FF PTS
N/A
Position Rank: 140th
Projected FF PTS
N/A
Week 22
Upside / Downside
-7
Week 22
Posted: 9/05/2025 9:45 pm GMT
San Francisco 49ers RB Jordan James (finger) and WR Jordan Watkins (ankle) were limited in practice all week and are listed as doubtful for Week 1 against the Seattle Seahawks. RB Christian McCaffrey (calf) did not practice on Friday, Sept. 5, and is listed as questionable. DL Yetur Gross-Matos (knee) did not practice and was not given a practice designation. G Ben Bartch (elbow), DL Kalia Davis (groin), RB Isaac Guerendo (shoulder), DL Bryce Huff (ankle), WR Jauan Jennings (calf), QB Mac Jones (knee), DL Sam Okuayinonu (shoulder), S Jason Pinnock (heel), G Dominick Puni (knee), CB Upton Stout (calf), DL CJ West (knee), DL Mykel Williams (knee), and OT Trent Williams (rest) practiced in full on Friday and no longer appear on the injury report.
Posted: 9/05/2025 9:45 pm GMT
San Francisco 49ers RB Jordan James (finger) and WR Jordan Watkins (ankle) were limited in practice all week and are listed as doubtful for Week 1 against the Seattle Seahawks. RB Christian McCaffrey (calf) did not practice on Friday, Sept. 5, and is listed as questionable. DL Yetur Gross-Matos (knee) did not practice and was not given a practice designation. G Ben Bartch (elbow), DL Kalia Davis (groin), RB Isaac Guerendo (shoulder), DL Bryce Huff (ankle), WR Jauan Jennings (calf), QB Mac Jones (knee), DL Sam Okuayinonu (shoulder), S Jason Pinnock (heel), G Dominick Puni (knee), CB Upton Stout (calf), DL CJ West (knee), DL Mykel Williams (knee), and OT Trent Williams (rest) practiced in full on Friday and no longer appear on the injury report.
Posted: 9/05/2025 9:40 pm GMT
San Francisco 49ers RB Isaac Guerendo (shoulder) fully participated in practice Friday, Sept. 5, and is not on the injury report for Week 1.
Huddle Up: Guerendo's fantasy value will depend on if Christian McCaffrey will be available for the game. He will receive most of the work at running back if McCaffrey is ruled out and can be at least a flex option in that situation. He can be avoided in most leagues if McCaffrey is active for the game.
Posted: 9/05/2025 9:40 pm GMT
San Francisco 49ers RB Isaac Guerendo (shoulder) fully participated in practice Friday, Sept. 5, and is not on the injury report for Week 1.
Huddle Up: Guerendo's fantasy value will depend on if Christian McCaffrey will be available for the game. He will receive most of the work at running back if McCaffrey is ruled out and can be at least a flex option in that situation. He can be avoided in most leagues if McCaffrey is active for the game.
Posted: 9/05/2025 12:51 am GMT
San Francisco 49ers RB Christian McCaffrey (calf), WR Jordan Watkins (ankle), DE Yetur Gross-Matos (knee), RB Jordan James (finger), WR Jauan Jennings (calf) and OG Dominick Puni (knee) were limited participants in practice Thursday, Sept. 4. OT Trent Williams (non-injury), OG Ben Bartch (elbow), DT Kalia Davis (groin), RB Isaac Guerendo (shoulder), DE Bryce Huff (ankle), QB Mac Jones (knee), DE Sam Okuayinonu (shoulder), S Jason Pinnock (heel), CB Upton Stout (calf), DT CJ West (knee) and DE Mykel Williams (knee) fully participated in practice.
Posted: 9/03/2025 11:24 pm GMT
San Francisco 49ers DE Yetur Gross-Matos (knee), WR Jordan Watkins (ankle) and OT Trent Williams (non-injury) did not participate in practice Wednesday, Sept. 3. RB Jordan James (finger), WR Jauan Jennings (calf) and OG Dominick Puni (knee) were limited during practice. OG Ben Bartch (elbow), DT Kalia Davis (groin), RB Isaac Guerendo (shoulder), DE Bryce Huff (ankle), QB Mac Jones (knee), DE Sam Okuayinonu (shoulder), S Jason Pinnock (heel), CB Upton Stout (calf), DT CJ West (knee) and DE Mykel Williams (knee) fully participated in practice.
Posted: 8/24/2025 8:53 pm GMT
San Francisco 49ers RB Isaac Guerendo might only be used as a No. 3 option in the San Francisco backfield following the acquisition of RB Brian Robinson Jr. "Brought (Robinson) here to be our 2-back," head coach Kyle Shanahan said Sunday, Aug. 24. "Always been a big fan of Brian."
Huddle Up: Guerendo appeared to be in line to be the primary backup, but an injury caused a need for the team, and they scooped up a guy who has been a starter in this league. If Robinson or Christian McCaffrey suffer an injury, all is not lost, but for now, Guerendo's fantasy appeal is at an all-time low.
Posted: 8/19/2025 7:12 pm GMT
San Francisco 49ers RB Isaac Guerendo (shoulder) returned to practice Tuesday, Aug. 19, according to ESPN.com's Nick Wagoner. Guerendo injured his shoulder on Aug. 2 during special teams drills.
Huddle Up: If healthy, Guerendo is expected to be the 49ers' No. 2 running back behind oft-injured Christian McCaffrey. For now, he remains one of the most valuable handcuffs in fantasy football.
Posted: 8/04/2025 7:25 pm GMT
San Francisco 49ers RB Isaac Guerendo (shoulder) will miss a few weeks because of a shoulder injury, according to head coach Kyle Shanahan.
Huddle Up: Guerendo probably will not see much playing time during the preseason and could be a question mark for the start of the regular season depending on the severity of the injury. He posted good numbers last season when Christian McCaffrey was not available but will have limited value this season with McCaffrey healthy again.
Posted: 8/02/2025 7:04 pm GMT
San Francisco 49ers RB Isaac Guerendo (arm) left practice early Saturday, Aug. 2, after suffering an apparent arm or shoulder injury.
Huddle Up: Fantasy players should keep an eye on the situation to see if Guerendo will miss some time because of the injury. He is in line to be primary backup running back for the 49ers this season and could have a good amount of fantasy value because of Christian McCaffrey's injury history. He can be a late round pick or handcuff to McCaffery in fantasy leagues.
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