Huddle Up: This was the expected move, and it's likely McCaffrey will miss the rest of the season. With Jordan Mason (ankle) also expected to land on IR, Isaac Guerendo will take the reins as San Fran's lead back and is a must-add player this week. The rookie has proven to be an explosive weapon in limited work and could be a solid RB2.

Huddle Up: It seems like McCaffrey will not play again this season but should be fine for the 2025 season. Isaac Guerendo likely will be the main running back for the 49ers moving forward since Jordan Mason is also dealing with an injury and he can be at least a flex option in most fantasy leagues.

Huddle Up: McCaffrey was initially listed as questionable to return, but it appears he'll miss time. Jordan Mason would step back into the starting job if CMC is, indeed, going to be done for a while. Isaac Guerendo would be the primary backup.

Huddle Up: McCaffrey likely didn't aggravate his Achilles injury, but it's no surprise to see McCaffrey injured with icy, snowy conditions in Orchard Park. We'll see if he comes back. If not, it will likely be a steady diet of Jordan Mason.

Huddle Up: McCaffrey will continue to be a significant part of the offense this week and should be a starting option in all fantasy leagues.

Huddle Up: McCaffrey should see plenty of touches again this week and is a must-start option in all fantasy leagues.

Huddle Up: McCaffrey did not have a lot of success last week but should continue to see plenty of touches moving forward. He is a weekly starting option in all leagues when healthy.

Huddle Up: With Brock Purdy out, and Brandon Allen under center, the Packers stacked the box and dared Frisco to pass the ball. CMC had tacklers in his face quickly, and he managed just 2.8 yards per rushing attempt. He even tapped out at one point for a breather, a rare break needed for CMC, as Jordan Mason had a few carries. It's been a slow-go for McCaffrey, who has yet to score in three games since returning. Sunday marked his first game under 100 total scrimmage yards, too, but that can be attributed to the QB situation. Still, fantasy managers who took McCaffrey either No. 1 or 2 overall saw him miss a huge chunk of the season, and now he is putting up RB2 caliber numbers. He'll look for his first visit to the end zone in Week 13 at Buffalo on Sunday Night Football.

Huddle Up: McCaffrey likely will receive a significant workload this week with Brandon Allen as the starting quarterback. He should be a starting option in all fantasy leagues.